Retatrutide is a peptide that activates three key metabolic pathways: the glucagon receptor (supporting energy expenditure and fat metabolism), the GLP-1 receptor (helping regulate appetite and satiety), and the GIP receptor (supporting insulin response and nutrient utilization). Through this combined action, it promotes improved glucose control, reduced hunger, and enhanced mitochondrial energy production. This multi-receptor activity enables a broad effect on metabolism, fat oxidation, and overall energy balance.

Typical dosage start at 0.5mg and should peak at 4mg per week as studies have show this to be the ideal delta between benefits and the potential for nausea side effects.